Fecha/hora: 20/05/2024 04:18:57

Biblioteca(s): 	INIA Las Brujas.	
Tipo de la producción científica: 	Artículos en Revistas Indexadas Internacionales	
Circulación/Nivel: 	Internacional - --	
Fecha corriente: 	15/04/2021	
Fecha de la última actualización: 	15/04/2021	
Autoria: 	COSTA, D.; LÉVESQUE, S.; KUMAR, N.; FRESIA, P.; FERRÉS, I.; LAWLEY, T. D.; IRAOLA, G.	
Afiliación: 	DANIELA COSTA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay; SIMON LÉVESQUE, Laboratoire de Santé Publique du Québec, Quebec City, Canada; NITIN KUMAR, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; PABLO FRESIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; IGNACIO FERRÉS, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; TREVOR D. LAWLEY, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; GREGORIO IRAOLA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Center for Integrative Biology, Universidad Mayor, Santiago de Chile, Chile.	
Título: 	Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts.	
Año de publicación: 	2021	
Fuente/Imprenta: 	Scientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9	
ISSN: 	2045-2322	
DOI: 	10.1038/s41598-021-82993-9	
Idioma: 	Inglés	
Notas: 	Article history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021.	
Contenido: 	ABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens. 
© 2021, The Author(s).	
Palabras-Clave: 	Computational biology and bioinformatics; Evolution; Microbiology.	
Categoría del tema: 	A50 Investigación agraria	
URL: 	https://www.nature.com/articles/s41598-021-82993-9.pdf	
Registro original: 	INIA Las Brujas (LB)	
Ejemplares: 	LB - (102642-1) - PXI - AP - DD - PP/Scientific Reports/2021 -  -  - DIS